Abstrakt

Long-term Effects of Multiple Glucocorticoid Exposures in Neonatal Mice

Hora Yaduo

Term poverties in neuromata function and cognition. We’ve preliminarily shown that a Gluco Corticoids (GCs) similar as Dexamethasone (DEX) or betamethasone are constantly administered for over to a month to precociously born babies as a treatment for habitual lung dysfunction. Results of clinical trials have shown that the use of GCs in these babies induces long single exposure to clinically applicable boluses of DEX or other GCs in the mouse during a period corresponding to the mortal perinatal period produces a dramatic increase in apoptotic cell death of neural ancestor cells in the developing cerebellum. To give a model approaching further habitual clinical dosing rules we estimated possible behavioral goods performing from repeated exposures to DEX and posterior GC convinced neuronal loss where neonatal mouse pups were fitted with3.0 mg/ kg DEX or saline on postnatal days 7 9 and 11 (DEX3 treatment). Adult DEX3 treated mice displayed long-term conceivably endless neuron motor poverties on a complex exertion wheel task which requires advanced- order motor collaboration chops. DEX3 mice displayed bloodied performance on this task relative to saline controls in each of two independent studies involving separate cohorts of mice. Histopathology studies exercising stereological neuronal counts conducted in behaviorally- tested mice showed that the DEX3 treatment redounded in a significant drop in the number of neurons in the internal scrap sub caste (IGL) of the cerebellum although the number of neurons in the Purkinje cell subs caste were unchanged. The results suggest that multiple neonatal DEX exposures can produce habitual poverties in fine motor collaboration that are associated with cerebellar IGL neuronal loss.