Abstrakt

Molecular Mechanisms Underlying Hepatocellular Carcinoma

Philippe Merle

Hepatocarcinogenesis is a complex process that remains still incompletely understood. That might be explained by the multifariousness of etiologic factors, the inheritable/ epigenetic diversity of excrescences bulks and the ignorance of the liver cell types that give rise to tumorigenic cells that have stem cell- suchlike parcels. The DNA stress convinced by hepatocyte development, inflammation and perhaps early oncogenic pathway activation and occasionally viral factors, leads to DNA damage response which activates the crucial excrescence suppressive checkpoints responsible of cell cycle arrest and cellular anility as reflected by the cirrhosis stage. Still obscure mechanisms, but perhaps involving the Wnt signaling and Twist proteins, would allow pre-senescent hepatocytes to bypass anility, acquire eternity by telomerase reactivation and get the last inheritable/ epigenetic successes necessary for cancerous metamorphosis. Among some of the oncogenic pathways that might play crucial driving places in hepato carcinogenesis, c- myc and the Wnt/- catenin signaling feel of particular interest. Eventually, anti pro liferative and apoptosis scarcities involving pathways for case are prerequisite for cancerous metamorphosis. Of substantiation, not only the converted liver cell per se but the easing medium is of abecedarian significance for excrescence bulk growth and metastasis.