Abstrakt

Quantity of Serum miRNA in the Patient Suffering From Acute Promyelocytic Leukemia

Anette Jacobs

To investigate the clinical Quantity of explicit miRNA in patients with Acute promyelocytic leukemia.129 patients with intense promyelocytic leukemia analyzed in emergency clinic from January 2015 to January 2020 were chosen as the perception bunch. Simultaneously, 74 patients with non-acute promyelocytic leukemia who went through bone marrow goal were incorporated as the benchmark group. The articulation levels of miR-126-5p and miR-13, unique trademark boundaries, and anticipation were thought about between the two gatherings, and the clinical meaning of miR-126-5p and miR-13 in intense promyelocytic leukemia was examined. The statement of miR-126-5p ( versus ) and miR-13 ( versus 21.66 ± 2.18) in the perception bunch was fundamentally lower than that in the benchmark group. The articulation level of miR-126-5p was essentially connected with lactate dehydrogenase level, HGB level, NPM1 freak type, and complete reduction. The articulation level of miR-13 was essentially associated with HGB level, NPM1 freak type, and complete abatement. Both articulation levels of miR-126-5p and miR-13 were not corresponded with sex, age, WBC, PLT, extent of bone marrow early stage cells, hepatomegaly, splenomegaly, lymph hub expansion, and FLT3-ITD. Cox multivariate relapse investigation showed that fringe blood WBC, bone marrow impact cell count, and miR-126-5p and miR-13 were prognostic elements in patients with intense promyelocytic leukemia. The awareness, explicitness, precision, and AUC of serum miR-126-5p forecast were 75.83%, 84.56%, 82.17%, and 0.729, separately. The awareness, explicitness, precision, and AUC of serum miR-13 forecast were 78.64%, 88.49%, 86.20% and 0.882, separately.