Abstrakt

Response of T cells during Ischemic Stroke in children

Ayesha Sheikh

Ischemic stroke, which occurs when blood flow to the brain is abruptly disrupted, is a leading cause of death and has a significant impact on children. Due to the strict time frames required for their administration, the currently available treatments for ischemic stroke are extremely limited and unsuitable for child patients. As a result, novel approaches to treatment are urgently required. Because of their role in ischemic stroke, T cells, part of the adaptive immune system have received more attention. In case of children, the adaptive immune system is under the consideration of gradual development. By considering this, T cells are assumed to be main role players in treatment strategy. T cells play contradictory roles in post-stroke inflammation and as potential therapeutic targets, according to clinical and per-clinical research. T cell recruitment mediators and the temporal course of their infiltration through the blood-brain barrier, choroid plexus, and meningeal pathways are summarized in this review. Besides, we portray the systems behind the pernicious and useful impacts of White blood cells in the cerebrum, in both antigen-ward and antigenfree habits, lastly we explicitly center on clinical and pre-clinical examinations that have explored Lymphocytes as expected remedial focuses for ischemic stroke.